巨噬细胞移动抑制因子在急性胰腺炎中的表达与CT分级的对比研究

Relationships between serum levels of macrophage migration inhibitory factor and CT grades in the patients with acute pancreatitis

目的研究急性胰腺炎(AP)患者血浆巨噬细胞移动抑制因子(MIF)含量的表达及相应的CT表现,并分析其临床意义。方法按照Balthazar分级将58例急性胰腺炎CT图像改变分为A、B、C、D和E共5个级别,各级别分别与相应的MIF含量相比较分析。结果A、B级(水肿型)时血浆MIF含量较对照组明显升高,差异有统计学意义(P<0.05);C、D、E级(出血坏死型)时MIF水平较对照组和急性水肿型胰腺炎组升高,差异有统计学意义(P均<0.05),且Balthazar CT分级评分与MIF水平呈正相关(r=0.637,P<0.05)。结论MIF在急性胰腺炎的发生、发展中起着重要作用,动态检测AP患者血浆中MIF含量有助于预测患者病情及指导临床诊断和治疗。

Objective To investigate the relationship between serum levels of macrophage migration inhibitory factor （MIF） and CT findings in the patients with acute pancreatitis （AP） , and to analyze its clinical significance. Methods 58 cases with AP were divided into A, B, C, D and E five grades based on Balthazar CT grades, and the CT grades were compared with the serum MIF. Results Compared with the control group （ 214. 1 ± 6. 3 ） g/mL, the serum MIF increased markedly in grade A （ 596.6 ± 7.9 ） pg/mL and grade B （ 658.4 ± 12.6 ） pg/mL （ P 〈 0.05 ） , and it was also higher significantly in grade C （3663.5 ±14.3） pg/mL, grade D （4630.6 ±14.6） pg/mL and E （5013.8±8.5） pg/mL with acute necrosis pancreatitis （ANP） than in normal subjects（NS） and acute edematous panereatitis （ AEP ） , and there were statistical differences （ P 〈 0.05 ）. Meanwhile, positive correlation was found between CT grades and serum levels of MIF （ r = 0. 637, P 〈 0.05 ）. Conclusion MIF plays an important role in the patients with acute pancreatitis. To detect dynamically serum levels of MIF in the patients with AP can be useful to predict the patient＇s condition and guide clinical diagnosis and treatment.