辅酶Q_10对体外循环中红细胞膜及免疫功能的保护作用

The protective effect of coenzyme Q_10 on red blood cell membrane and its immunity in patient during extracorporeal circulation

目的:观察辅酶Q_10对体外循环病人红细胞膜及免疫功能的保护作用。方法:体外循环时间30分钟左右的病人20例随机分为对照组和Q_10组,每组10例,Q_10组在体外循环预充液中加入辅酶Q_102mg/kg。二组均于转机前、转机15分、30分钟及次日上午取静脉血测丙二醛(MDA)、游离血红蛋白(FHb)及红细胞免疫粘附功能(R-CIA)、红细胞膜免疫复合物(R-CIC)。结果:Q_10组转机15分钟后MDA、FHb低于对照组而R-CIA高于对照组。结论:辅酶Q_10能较好地保护体外循环病人的红细胞膜及免疫功能。

Objective: To study the protective effect of coenzyme Q_10 on red blood cell membrane and its immunity in patient during extracorporeal circulation. Method: Twenty patients under extracorporeal circulation about 30 minutes were randomly divided into control group and coenzyme Q_10 group (n=10). Coenzyme Q_10 2mg/kg was added to the priming fluid in coenzyme Q_10 group. Plasma levels of malondialdehyde (MDA), free hemoglobin (FHb), immune adhe sion ability and immune compound of red blood cell membrane were measured before extracorporeal circulation, 15 and 30 minutes after beginning of cardiopulmonary bypass, and on first day morning after operation. Result; All different periods after beginning of cardiopulmonary bypass in coenzyme Q_10, group, MDA and FHb levels were lower and im mune adhesion ability was higher than those of control group. Conclusion: Coenzyme Q_10 may protect red blood cell membrane and its immunity of patient during extracorporeal circulation.