多囊卵巢综合征患者促排卵治疗中机械刺激子宫内膜提高妊娠率观察

The observation of increasing pregnancy rate by mechanically stimulating endometria during facilitating ovulation treatment in polycystic ovarian syndrome patients.

目的研究在多囊卵巢综合征患者促排卵治疗中的机械刺激子宫内膜提高妊娠成功率的作用。方法54例育龄期多囊卵巢综合征不孕症患者用达因-35联合二甲双胍治疗3～6个周期后,用克罗米芬促排卵治疗,其中27例多囊卵巢综合征患者在停用用达因-35次月,于卵泡期(于月经第8～10d)机械刺激子宫内膜,以10例有正常月经周期及排卵为对照组。结果PCOS患者对症治疗除了可以降低雄激素还间接起到保护子宫内膜的作用,活检能够筛查出早期病变。结论(1)高雄激素状态及高LH水平是多囊卵巢综合征的重要病理特征。(2)机械刺激子宫内膜能提高多囊卵巢综合征患者促排卵治疗的临床妊娠率。

Objective To explore the method of increasing successful pregnancy rate by mechanically stimulating endometria in polycystic ovarian syndrome （PCOS） patients during facilitating ovulation treatment. Methods 54 child-bearing period PCOS barrenness patients were firstly treated by combining Diane-35 and Mefformin Hydrochloride for 3 to 6 weeks, then were taken clomiphene to stimulate ovulation. Among the total PCOS patients, 27 patients were mechanically stimulated endometria at follicular phase （the 8th to lOth day of menses） the next month after stop using Diane-35. The controls were 10 patients with normal menstrual cycle and ovulation.Results PCOS patients were treated in term of symptoms,it could not only decrease luteinizing hormone but also protected endometria indirectly,the biopsies could screen the earlier diseases. Conclusion （ 1 ）High androgen status and high luteinizing hormone are the important pathologic characteristics of PCOS. （2） Mechanically stimulating endometria are able to promote the clinical pregnancy rate of PCOS patients with stimulating ovulation.