己酮可可碱对肠缺血再灌注致多器官损伤的保护作用

Protective effects of pentoxify Lline on multiple organ injury caused by gut ischemia reperfusion

目的:研究多形核中性粒细胞(PMN)在多器官损伤中的作用及PMN活化的抑制剂己酮可可碱对器官损伤的保护作用。方法:采用大鼠肠缺血再灌注致多器官损伤的模型。结果:肠缺血再灌注可导致肠及远端器官肝、肺中PMN聚集明显增加,并伴有这些器官的损伤;己酮可可碱可明显抑制肠缺血再灌注引起的PMN聚集,同时肠、肝、肺组织损伤的指标明显改善。结论:肠缺血再灌注造成PMN在肠及远端器官中的聚集增多,是导致多器官损伤的重要原因;己酮可可碱可减轻肠缺血再灌注引起的多器官损伤,这一作用至少部分是通过抑制PMN的活化和聚集而实现的。

Objective: To study the role of polymorphonuclear neutrophils (PMNs)in causing mutiple organ injury and the protective effects of an inhibitor of PMNs activating, pentoxifylline(PTX) on organs injury. Method: A rats model of gut ischemia/reperfusion(I/R) was used. Result:Gut I/R caused the increase of PMNs sequestration in gut and remote organs of lung and liver ,along with the organs injuryies. PTX markedly decreased the PMNs sequestra tion caused by gut I/R in gut. liver, and lung(P<0.O1). PTX also markedly ameliorated these organs injury (P<0.05 or P<0.01). Conclusion: PMNs sequestration importantly contributes to organ injury caused by gut I/R, PTX can protect organ from injury caused by gut I/R, and this protective effect is at least partly due to PTX's inhibitive effects on PMN activating and sequestration.