疏肝健脾法治疗肝郁脾虚型抑郁症的临床研究

Treatment of depression of liver-qi stagnation and spleen-deficiency type with therapy of soothing liver and invigorating spleen

目的观察疏肝健脾法治疗肝郁脾虚型抑郁症的临床疗效。方法采用随机、对照、盲法原则,选取符合轻、中度抑郁症及中医肝郁脾虚型证候标准的60例患者,随机分为两组,治疗组和对照组各30例。治疗组予疏肝健脾法(口服逍遥散)治疗,对照组予西药氟西汀胶囊,疗程均为6周。结果①按中医疗效指数评估临床疗效,两组总有效率比较,治疗组明显优于对照组(P<0.01);②按HAMD评分评估临床疗效,治疗组与对照组疗效相当(P>0.05);③治疗组在食欲下降、腹胀、入睡难、口干口苦及多梦等症状的疗效上优于对照组(P<0.01或P<0.05);④应用逍遥散治疗,未见到不良反应。结论疏肝健脾法治疗肝郁脾虚型抑郁症具有较好的疗效,且无明显的毒副作用,提示中医辨证治疗抑郁症具有一定的优势。

Objective To observe the curative effect of the therapy of soothing liver and invigorating spleen on the depression of liver-qi stagnation and spleen-deficiency type. Method According to the principle of random, control and blindness, 60 patients with mild or moderate depression of liver-qi stagnation and spleen-deficiency type were randomly divided into two groups （each n = 30）. The treatment group was given Xiaoyao Powder orally according to the 6 weeks, and the control group was given Fluoxetine therap Capsules y of soothing liver and invigorating spleen for for 6 weeks. Results （1）The curative effect was assessed according to TCM Curative Effect Index, the total effective rate in the treatment group was much higher than that in the control group （P 〈 0.01 ）. （2）The curative effect assessed according to HAMD score showed that there was no difference between two groups （ P 〉 0.05 ）. （3）In the treatment group the effects on some symptoms including poor appetite, abdominal distension, insomnia, dry and bitter taste of mouth were better than those in the control group （P 〈 0.01 or P 〈 0.05 ）. （4）There was no any side effects observed in the treatment with Xiaoyao Powder. Conclusion The therapy of soothing liver and invigorating spleen has a good curative effect on the depression of liver-qi stagnation and spleendeficiency type without side effects, which indicates that Chinese medicine has an advantage in the treatment of depression.