期刊文献+

液质联用技术在药物分析中的应用研究进展 被引量:15

Recent Development in the Application of Liquid Chromatography-Mass Spectrometry in Pharmaceutical Analysis
下载PDF
导出
摘要 液相色谱-质谱联用技术以其高分离能力,高灵敏度,和专属性强的优势,在药物成分的鉴定分析、药物代谢研究、中成药和保健品中非法添加化学药物成分的鉴定分析以及药物残留分析等方面得到广泛的应用。本文简要综述了近年来液质联用技术在药物分析中的应用,为进一步扩大应用提供参考。 Liquid chromatography-mass spectrometry is regarded as an important technology for many advantages such as high separating efficiency, good sensitivity and strong specifity. So it is widely used in analysis of drugs and metabolites, chemical medicine mixed illegally in Chinese medicine and drug residues. This paper briefly reviewed its application in pharmaceutical analysis, offering reference for further application.
出处 《中国药品标准》 CAS 2008年第6期443-446,共4页 Drug Standards of China
关键词 液质联用技术 药物分析 药物代谢 应用 liquid Chromatography-mass spectrometry (LC-MS) pharmaceutical analysis drug metabolism application
  • 相关文献

参考文献37

  • 1袁杰,龚又明,鞠鹏,孔令义.HPLC-MS^2法分析朝鲜淫羊藿中的化学成分[J].中草药,2004,35(4):371-374. 被引量:22
  • 2[3]Kite G C,Howes M J,Simmonds M S.Metabolomic analysis of saponins in crude extracts of Quillaja saponaria by liquid chromatography /mass spectrometry for product authentication[J].Rapid cammun Mass Sp,2004,18 (23):2859-2870
  • 3[4]Shui G,Leong L P.Analysis of polyphenolic antioxidants in star fruit using liquid chromatography and mass spectrometry[J].J Chromatogr A,2004,1022(1-2)67-75
  • 4[6]Parejo I,Jauregui O,Sanchez-Rabaneda F,et al.Separation and characterization of phenolic compounds in fennel (Foeniculum vulgare) using liquid chromatography-negative electrospray ionization tanderm mass spectrometry[J].J Agr Food Chem,2004,52(12):3679-3687
  • 5贾强,白杨,马燕,彭维,苏薇薇.枳壳和枳实化学成分的HPLC-ESI-MS分析[J].中草药,2005,36(2):169-172. 被引量:54
  • 6沈金灿,卢素格,庄峙厦,王小如,Frank S.C.Lee.甘草提取物的液相色谱质谱联用分析[J].现代中药研究与实践,2004,18(B12):16-18. 被引量:11
  • 7[9]Luchtefeld R,Kostoryz E,Smith R E.Determination of ginsenosides Rb1,Rc,and Re in different dosage forms of ginseng by negative ion electrospray liquid chromatography-mass spectrometry[J].J Agr Food Chem,2004,52 (16):4953-4956
  • 8朱国元,陈光英,李庆洋,沈小玲,方宏勋.HPLC/MS/MS技术在中药白花前胡成分鉴定中的应用[J].中国天然药物,2004,2(5):304-308. 被引量:16
  • 9裴渭静,郑晓晖,赵新锋,赵文明.HPLC-MS^n法筛选丹参中丹酚酸类成分的SPE预处理工艺[J].中成药,2004,26(10):840-843. 被引量:5
  • 10[14]Cui L,Abliz Z,Xia M,et al.On-line identification of phenanthroindolizidine alkaloids in a crude extract from Tylophora atrofolliculata by liquid chromatography combined with tandem mass spectrometry[J].Rapid Conmun Mass Sp,2004,18 (2):184-190

二级参考文献149

共引文献397

同被引文献301

引证文献15

二级引证文献253

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部