摘要
目的制备苦参碱缓释片并考察其释放度。方法以羟丙基甲基纤维素和乙基纤维素为骨架材料,制备了1天给药2次的苦参碱缓释片,并进行体外累积释放度测定。结果苦参碱缓释片体外释药曲线符合H iguch i方程,r=0.999 0。结论该缓释片处方工艺简单可行,缓释效果明显。
Objective To prepare matrine sustained-release tablets and evaluate its release characteristics.Methods The matrine sustained-release tablets was prepared with HPMC and EC.The release rate of sustained-release tablets was tested by HPLC method.Results The release curve of matrine sustained-release tablets conformed to Higuchi formula,with r=0.999 0.Conclusion The method was simple and feasible,and the product had obvious sustained-release effects.
出处
《广东药学院学报》
CAS
2008年第6期569-571,共3页
Academic Journal of Guangdong College of Pharmacy