健康成人135例心率变异性时域分析

Time domain analysis of heart rate variability in 135 healthy adults

目的：探讨国人心率变异时域分析各项指标的正常值。方法：应用清华－西安兰港监测系统对１３５例１８～７９岁健康成人连续２４ｈ动态心电图监测。结果：①心率变异性时域：ＳＤＮＮ、ＳＤＳＤ、ＳＤＡＮＮ、ＲＭＳＳＤ、ＰＮＮ５０分别为１２９．５２±２７．２５ｍｓ；２１．１８±８．２０ｍｓ；１１４．７８±２６．８４ｍｓ；３１．３６±１２．６７ｍｓ；８．５０ ± ７．８０ｍｓ，所测得正常值范围与国内外研究结果相似。②１８～３５岁组、３６～５９岁组，均与≥６０岁组有非常显著的差异（Ｐ＜０．０１，或Ｐ＜０．０５）。③各年龄组男女间ＳＤＮＮ、ＳＤＳＤ、ＰＮＮ５０无显著差异（Ｐ＞０．０５），但ＳＤＡＮＮ男性较女性大（Ｐ＜０．０５）；女性ＲＭＳＳＤ较男性大（Ｐ＜０．０５）。结论：ＳＤＮＮ＞１００ｍｓ；ＳＤＳＤ＞１２ｍｓ；ＳＤＡＮＮ＞８７ｍｓ；ＲＭＳＳＤ＞１８ｍｓ；ＰＮＮ５０＞０．７％可作为ＨＲＶ时域分析参考正常值。

Objective: to investigate normal values of the time domain indices of heart rate variability (HRV) in Chinese adults. Methods: 135 healthy subjects aged from 18 to 79 years old were examined by 24-hour ambulatory electrocardiograph. Results: ① The time domain indices of HRV: the standard deviation of all normal RR intervals (SDNN), the standard deviation of successive difference (SDSD), the standard deviation of the average normal R-R intervals for 5-minute segments (SDANN ), the root mean square successive difference (RMSSD) and percentage of differences between normal R-R intervals that exceed 50 ms (PNN50) were 129.52 ±27 .25 ms, 21. 18 ±8.20 ms, 114.78 ± 26.84 ms, 31 .36 ± 12.67 ms, 8. 50 ± 7. 80%, respectively. ②there were significant differences between the groups of 18-35 years old, 36-59 years old and exceed or equaled 60 years old (P < 0 .05, P < 0 .01 ). ③SDANN of healthy men was greater than that of healthy women (P < 0. 05 ), whereas women' s RMSSD was greater than men's (P < 0 .05 ), Conclusions: normal values of the time domain indices of HRV in chinese healthy adults may be SDNN > 100 ms, SDSD > 12 ms, SDANN > 87 ms, RMSSD > 18 ms and PNN50 > 0.7%.