三维适形放疗联合药物治疗腹膜后肿瘤所致重度疼痛的临床观察

Observation of 3-DCRT combined with morphine in treatment with severe cancer pain caused by retroperitoneal tumors

目的观察三维适形放疗联合药物治疗腹膜后肿瘤所致重度疼痛的疗效。方法对38例腹膜后肿瘤患者行三维适形放疗2.5～3.5 Gy/次,总剂量42～49 Gy。同时联合阿片类药物治疗腹膜后肿瘤所致重度疼痛,观察疼痛变化和药物剂量变化。结果治疗后疼痛减轻,药物剂量减少,治疗前后VAS比较差异有显著性(P<0.01),不良反应主要为便秘,恶心,呕吐。结论三维适形放疗联合药物治疗腹膜后肿瘤所致重度疼痛可使疼痛明显减轻,药物用量减少,治疗效果较好。

Objective To investigate the efficacy of 3-DCRT combined with morphine in treatment of severe cancer pain caused by retroperitoneal tumors. Methods Thirty-eight patients with retroperitoneal tumors were treated with 3DCRT 2. 5-3. 5 Gy/fraction, with a total dose of 42-49Gy, and morphine. The changes of cancer pain and drug dose were observed. Results Cancer pain was relieved and drug dose was reduced after treatment. VAS score before treatment was significantly higher than that after treatment with 3- DCRT and morphine（P 〈 0. 01 ）. Constipation, nausea, vomiting were main side effects. Conclusion Cancer pain can be relieved and drug dose can be reduced after treatment with 3-DCRT combined with morphine. The therapeutic efficacy is good.