摘要
目的:比较静脉滴注(静滴)尼卡地平和硝普钠治疗高血压急症病人的疗效及安全性。方法:高血压急症83例随机分为2组。尼卡地平组42例先静脉注射尼卡地平2mg,5min后以2.5mg/h静滴,继而每隔5min以2.5mg递增至有效剂量(DBP<13.3kPa),最大有效剂量不超过30mg/h,维持该剂量共24h。硝普钠组41例开始给硝普钠0.5μg/(kg·min),继而每隔5min以0.5~1.5μg/(kg·min)递增,达有效剂量即维持该剂量静滴24h[最大剂量<10μg/(kg·min)]。结果:尼卡地平组降压起效时间(6.0±1.1min)显著快于硝普钠组(17.0±2.6min),P<0.01;不良反应发生率(14%)低于硝普钠组(44%),P<0.05。结论:尼卡地平组起效快,且安全,优于硝普钠组。
AIM: To compare the clinical effects of iv drip nicardipine and sodium nitroprusside in treating hypertension emergencies. METHODS: Eighty_three hypertension emergencies were divided into 2 groups randomly. In nicardipine group 42 patients were given 2 mg iv and increased by 2.5 mg/h every 5 min until good result (DBP<13.3 kPa) and then maintained at the same dose intravenous infusion for 24 h(the maximum amount of dosage was 30 mg/h). In sodium nitroprusside group 41 patients were infused at 0.5μg/(kg·min) and increased by 0.5_1.5 μg/(kg·min) every 5 min until good result and maintained at the same dose for 24 h[the maximum amount of dosage was 10 μg/(kg·min)]. RESULTS: Both drugs reduced blood pressure, but iv nicardipine controlled hypertension more rapidly then sodium nitroprusside(iv nicardipine 6.0 ± 1.1 min, and sodium nitroprusside 17.0±2.6 min, P< 0.01). Adverse reactions were observed with both drugs [iv nicardipine 14%(6/42) and sodium nitroprusside 44%(18/41), P[WTBZ]<0.05]. CONCLUSION: Nicardipine is quicker effective and less adverse reaction than sodium nitroprusside in treating hypertension emergencies.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1998年第3期138-140,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
高血压
急症
尼卡地平
硝普钠
静脉滴注
nicardipine
sodium nitroprusside
hypertension
intravenous infusions