吲哚美辛对急性颅脑损伤颅内压的影响

Effect of indometacin on intracranial pressure in patients with acute brain injury

目的：探讨吲哚美辛对急性颅脑损伤颅内压（ＩＣＰ）的影响。方法：急性颅脑损伤病人３０例（男性２１例，女性９例；年龄３２±ｓ９ａ），在常规治疗（２０％甘露醇、细胞色素Ｃ、脑活素静脉滴注）基础上采用吲哚美辛片２５ｍｇ，ｐｏ，ｔｉｄ，共７ｄ；另设急性颅脑损伤病人３０例（男性２０例，女性１０例；年龄３１±８ａ）仅用常规治疗作对照。分别测定２组治疗前后ＩＣＰ和格拉斯哥昏迷分级表（ＧＣＳ）计分的变化。结果：治疗７ｄ后，前组ＩＣＰ显著低于后组（Ｐ＜０．０１），而ＧＣＳ计分前组显著高于后组（Ｐ＜０．０５）。结论：吲哚美辛具有降低急性颅脑损伤ＩＣＰ和促进脑功能恢复的作用。

AIM: To study the effect of indometacin on intracranial pressure (ICP) in patients with acute brain injury. METHODS: Thirty patients (M 21, F 9; age 32±s 9 a) with acute brain injury were treated conventionally with 20% mannitol 125 mL, iv, drip, q 6 h,cytochrome C 30 mg, cerebrolysin 20 mL in 10% glucose 500 mL, iv, drip, qd, for 7 d, and treated with indometacin 25 mg, po, tid, for 7 d; Another 30 patients (M 20, F 10; age 31±8 a) received conventional therapy only. The ICP and Glasgow Coma Scale (GCS) count were de_ tected before and 7 d after treatment. RESULTS: After treatment for 7 d, the ICP in indometacin group was lower than that in control group (P < 0.01), but the GCS count in indometacin group was higher than that in control group (P<0.05). CONCLUSION: Indometacin treating the patients with acute brain injury, reduces ICP and promotes recovery of brain function.