二茂铁亚胺环钯化合物催化的带有导向基团的sp^2 C-H键底物的邻位芳基化

Cyclopalladated Ferrocenylimine Catalyzed ortho-Arylation of sp^2 C—H Bond Substrates Containing the Directing Group

发展了一种以二茂铁亚胺环钯化合物为催化剂,对带有导向基团的sp2C—H键芳基底物进行邻位芳基化的新颖高效的催化体系.实验结果表明,反应表现出明显的区域选择性,芳基化只发生在空间位阻较小的sp2C—H键上,反应可以采用多种取代基(如CH3O,CH3CO,Br和Cl)进行,这有助于通过进一步反应构建更为复杂的新化合物.

A novel and efficient catalytic system for ortho-arylation of sp2 C—H bond substrates containing the directing group using cyclopalladated ferrocenylimine as catalyst was developed.The arylation showed high regioselectivity and only occurred on the less sterically hinderd ortho-C—H bond.The reaction could be compatible to diverse functional groups such as CH3,CH3O,and CH3CO,as well as Br and Cl substituents,which would permit to be functionalized further to construct new compounds with more complicated structures.