摘要
为研究抗癌基因ｎｍ２３在乳腺癌的表达及与组织学分型、分级、淋巴结转移的关系，应用免疫组Ｓ－Ｐ法，对３５例乳腺良性病变及１３８例乳腺癌进行ｎｍ２３检测分析。结果，ｎｍ２３在乳腺良性病变及癌中的阳性率分别为５７．１％（２０／３５），６０．１％（８３／１３８），两者无明显差别，但乳腺癌中ｎｍ２３的表达与组织学分级及淋巴结转移情况有极显著差异Ｐ＜０．０５～０．０１。研究表明，ｎｍ２３不能用于乳腺良、恶性病变的鉴别，但与乳腺癌的分级、转移呈显著负相关。提示ｎｍ２３在肿瘤的浸润、转移中发挥重要作用，ｎｍ２３的检测能预示肿瘤的转移和预后。
nm23 expression was studied immunohistochemically in 35 cases breast benign diseases and 138 cases breast cacinomas.The incidencees of nm23 expression in breast benign diseases and breast carcinomas were 57.1%(20/35)and 60.1%(83/138)(P>0.05),reduced nm23 expression correlated with poor-differentiation and lymph node metastasis(P<0.05,P<0.01).It is suggested that nm23 palys an important role in the invasion and metastasis of breast cancer,the expression of nm23 is an important index for metastasis and prognosis of breast cancer.
出处
《南通医学院学报》
1998年第2期152-153,共2页
ACTA Academiae Medicinae Nantong
