2-烯基-4(1H)-喹诺酮的合成及生物活性研究

STUDIES ON SYNTHESIS AND BIOACTIVITY OF2ALKENYL4(1H)QUINOLONE

采用两种方法合成了３个２烯基４（１Ｈ）喹诺酮（Ｉ～ＩＩ），其中化合物ＩＩ是从吴茱萸中分离得到的新化合物，其余２个化合物尚未见文献报道。并对所合成的化合物及中间体进行了初步药理试验，表明有一定的扩张血管和抗菌作用。

Three 2alkenyl4(1H)quinolone compounds(I～III) were synthesized by two methods. III is a new compound from Evodia rutaecarpa and was synthesized through the reaction of the aldehyde intermediate(5) with Wittig reagent. The other two compounds were synthesized for the first time. These compounds showed vasodilating and antibacteria effects in pharmacological tests.