应用氢呼气试验对乳糖酶缺乏症的研究

Hydrogentest breathing with different quantity of lactose in detecting lactase deficiency disease

目的：探讨国人对乳糖耐受性。方法：采用不同剂量乳糖进行氢呼气试验。对１３６名健康汉族成人分为３组，Ａ，Ｂ，Ｃ组乳糖负荷量分别为２５ｇ，１２．５ｇ，６．２５ｇ。Ｄ组为从Ｃ组氢呼气试验阴性中再给予１２．５ｇ乳糖重复试验。结果：Ａ，Ｂ，Ｃ，Ｄ组乳糖吸收不良发生率分别为８５．０％，４８．９％，２．０％和４６．７％；乳糖不耐受率分别为５４．３％，３０．４％，２．０％和２０．０％。Ａ，Ｂ，Ｃ组乳糖吸收不良发生率及乳糖不耐受率均有极显著性差异（Ｐ＜０．００１）；Ｂ，Ｄ组间均无显著性差异（Ｐ＞０．０５）。结论：国人乳糖耐受量为６．２５ｇ，饮用牛奶每次以１２５ｍｌ为合理营养。

OBJECTIVE: To find out the tolerance to lactose of Chinese. METHODS: Hydrogen breathing test (HBT) was used in 136 healthy adults of the Han nationality with different quantity of lactose A, B, C. The different groups of subjects were given 25 g, 12.5 g, 6.25 g lactose respectively. The subjects of the C group taking lactose with HBT negative were given 12.5 g lactose again were included the in D group. RESULTS: The test showed that the incidence of malabsorption for lactose of the A, B, C, D groups was respectively 85.0%, 48.9%, 2% and 46.7%. The intolerance was 54.3%, 30.4%, 2.0% and 20.0% respectively. The incidence of malabsorption of and intolerance to lactose were significently different among the A, B and C groups (P<0.001). There was no significant difference between the B and D groups (P>0.05). CONCLUSION: The tolerance quantity of lactose for Chinese is 6.25 g. Taking 125 ml milk for each time is reasonable.