有机磷中毒患者尿白蛋白和尿β_2微球蛋白的临床意义

Measurement of albuminuria and urinary β_2-microglobulin in patients with acute organophosphorus pesticide poisoning

目的:探讨急性有机磷农药中毒(AOPP)患者尿白蛋白(Alb)和尿β2微球蛋白(β2-MG)检测的意义。方法:用放射免疫法测定31例急性有机磷农药中毒患者的尿白蛋白和尿β2微球蛋白,并与34例健康正常人做对照。结果:31例AOPP患者中毒后尿常规或肾功能异常有12例,总阳性率为38.7%。中毒后尿白蛋白和尿β2微球蛋白开始增高,中毒后第3、5 d尿白蛋白及尿β2微球蛋白均高于正常对照(P<0.05),且中毒愈重,尿白蛋白和尿β2微球蛋白增高愈明显。结论:尿白蛋白和尿β2微球蛋白检测对AOPP患者早期肾损害的诊断具有重要意义。

Objective：To evaluate the clinical significance of measuring albuminuria and urinary β2-microglobulin in patients with acute organophosphorus pesticide poisoning （ AOPP ）. Methods ： Radioimmunoassay technique was used to measure the albuminuria and urinary β2-microglobulin in 31 patients with AOPP and 34 healthy subjects were recruited as controls for comparing the results. Results ： Of the 31 patients with AOPP, routine urine test on renal function was found positive in 12（38.7% ）. The level of albuminuria and urinary β2-microglobulin increased with progression of the poisoning, in particular, both levels were found higher than that of the controls on day 3 or 5 after intoxication（ P 〈 0.05）. Still, the more severe cases suggested a marked higher level of albuminuria and urinary β2-microglobulin. Conclusion ： The measurement of albuminuria and urinary β2-microglobulin is of great clinical significance in assessing early kidney injury with AOPP.