摘要
目的为研究丙型肝炎病毒(HCV)的母婴宫内传播,评估HCV母婴传播的危险性。方法应用酶联免疫吸附试验(ELISA)法检测HCV,以逆转录-聚合酶链反应(RT-PCR)检测HCV-RNA。结果检测的4277例孕晚期孕妇血清抗-HCV,其中6例阳性,进一步检查HCV-RNA,结果6例中有5例阳性,且均有受血史,5例阳性孕妇其配对婴儿脐血抗-HCV均阳性,其中2例HCV-RNA阳性,肝功能异常;1例出生时HCV-RNA阴性,到24个月时HCV-RNA阳转。HCV母婴宫内传播率为2/5。结论表明上海地区存在HCV母婴宫内传播,应重视有受血史的生育妇女孕期及孕前的HCV检查及HCV感染儿的随访。
Objective To study the maternal fetal transmission of hepatitis C virus (HCV) and to evaluate its risk.Methods Enzyme linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT PCR) techniques were used in this study. Results A total of 4 277 pregnant women were screened for their serum anti HCV antibody during the third trimester. Six pregnant women were anti HCV positive. HCV RNA was further detected using RT PCR technique. It was found that 5 out of 6 anti HCV seropositive women were HCV RNA positive and they all had history of blood transfusion. Five neonates born to HCV infected mother were also found to be anti HCV positive. Among them two were HCV RNA positive and had abnormal hepatic functions. One of those neonates who were HCV RNA negative at birth was found to be HCV RNA positive at 24 months of age. Therefore, the maternal fetal transmission rate of HCV was 2/5.Conclusion Maternal fetal transmission of HCV exists in Shanghai. It is necessary for all the child bearing aged women who had history of blood transfusion to have their serum HCV tested before conception and during pregnancy. Meanwhile, the infected neonates should be followed up.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1998年第5期296-298,共3页
Chinese Journal of Pediatrics
基金
上海市科学技术发展基金
关键词
垂直疾病传播
丙型肝炎
母婴传播
Hepatitis C viruses Disease transmission, vertical Hepatitis C