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新生儿缺氧缺血性脑病血清中Par-4蛋白与S100b蛋白含量水平变化及临床研究 被引量:1

The Level Changes and Clinical Researeh of Par-4 Protein and S100b Protein in Serum with Hypoxic Ischemic Encephalopathy
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摘要 目的:测定新生儿缺氧缺血性脑病(HIE)患儿血清中Par-4蛋白及S100b蛋白含量,探讨其临床意义。方法:采用ELISA法检测104例HIE患儿血清中Par-4蛋白及S100b蛋白量,并设立对照组。结果:HIE组患儿的Par-4蛋白及S100b蛋白量显著高于正常对照组(P<0.01),HIE患儿血清中的高阴离子间隙(AG)患儿的Par-4蛋白及S100b蛋白量显著高于正常AG患儿(P<0.01)。HIE患儿治疗一周后,Par-4蛋白及S100b蛋白量均显著回降(P<0.01)。结论:测定HIE患儿血清中Par-4蛋白及S100b蛋白对HIE疾病程度和治疗效果的判断都有重要的临床意义。 Objective: Through detecting the content of Par-4 protein and S100b protein in serum of neonates with hypoxic is chemic encephalopathy( HIE), to explore its clinical significance. Methods :The content of Par-4 protein and S100b protein in scram were measured in 104 neonates with HIE using enzyme- linked immuradsorbent assay(ELISA) and the controls were set up. Results:The content of Par-4 Protein and S100b protein in neonates with HIE were higher than those of controls ( P 〈 0.01 ). The content of Par - 4 protein and S100b protein in neonates with HIE with high AG were obviously higher than those with normal AG( P 〈0.01 ). After the neonates with HIE were treated in a week, the content of Par-4 protein and S100b protein was declined obviously ( P 〈 0.01 ). Clnclusion:Detecting the content of Par-4 protein and S100b protein in scram of the neonates with HIE has obvious clinical significanees in the judgements of the seriousness and the treating effect for HIE.
出处 《赣南医学院学报》 2008年第6期808-809,共2页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词 Par-4蛋白 S100B蛋白 缺氧缺血脑病 新生儿 Par-4 protein S100b protein hypoxic isehemic (HIE) encephalopachy neonate
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