4-正丁基邻苯二胺的制备

Synthesis of 4-N-Butyl-O-Phenylenediamine

以对正丁基苯胺为原料,经过酰化、硝化、水解、还原等四步反应,合成了4-正丁基邻苯二胺,总收率可达71.5%。首先将乙酰化和硝化合为一锅煮制备4-正丁基-2-硝基乙酰苯胺,再以甲醇作溶剂,碱性水解后直接以钯炭为催化剂,在50℃、0.5 MPa条件下反应成功制备了4-正丁基邻苯二胺。

P, n--butylaniline was used as raw material. The processes were acylation, nitration, hydroly- sis and reduction. The total yield of 4--n--butyl--o--phenylenediamine is 71.5%. First acylation and ni- tration were held in one pot to obtain 4--n--butyl--2--niroacetanilide. Then methanol was used as solvent. After alkaline hydrolysis Pd/C was used as catalyst at 50 ℃, 0. 5 MPa to obtain 4--n--butyl--o-- phenylenediamine.