摘要
纤维蛋白原（Fg）水平增高是导致缺血性心脏血管病发病的一个独立因素。Fg水平与遗传、年龄、性别、肥胖、血脂、吸烟、炎症和感染等因素相关，而遗传因素的致病作用已日益受到关注。近年来，已报道了10多个FgBβ基因多态性位点，其中-148C／T、－455G／A和－854G／A被认为与Fg水平增高显著相关，并可能是影响缺血性脑血管病发病的遗传性危险因素中最关键的因素之一。
The increased level of fibrinogen （Fg） is an independent factor that resulting in the occurrence of ischemic cardio-cerebrovascular diseases. The Fg level is correlated with heredity, age, sex, obesity, lipid, smoke, inflammation and infection, and the pathogenic effect of genetic factor has been increasingly receiving attention. In recent years, more than 10 FgBβ gene polymorphisms have been reported, among them, - 148C/T, - 455G/A, and - 854G/A are considered to be significantly correlated with the increased level of Fg, and may be one of the most key factors in influencing the genetic risk factors of the occurrence of ischemic cerebrovascular disease.
出处
《国际脑血管病杂志》
2008年第12期943-946,共4页
International Journal of Cerebrovascular Diseases
关键词
纤维蛋白原
基因多态性
缺血性脑血管病
fibrinogen
gene polymorphism
ischemic cerebrovascular disease
