血清涎酸测定在食管癌诊断及动态监测中的意义

The Clinical Singnificance of Serum Sialic Acid Measurement in the Diagosis and Dynamic Inspection of Esophageal Cancer

目的：研究血清涎酸（SA）对食管癌诊断及监测的临床价值。方法：采用HondaS改良的荧光测定法，对107例食管癌，83例良性疾病患者和103例健康人进行血清SA测定。结果：食管癌组患者血清SA含量显著高于良性疾病组和健康人组（P＜0．01）；不同组织类型和临床分期的食管癌患者血清SA水平间也有明显差异，血清SA水平与肿瘤的去分化程度和临床分期成正比关系；食管癌根治术4周后的血清SA水平显著低于术前（P＜0．01）；食管癌复发或有转移，则血清SA会再次明显升高或持续在高水平。结论：血清SA的测定对食管癌诊断。疗效观察及术后监测具有显著的临床价值。

Objective: To study the clinical significance of serum sialic acid (SA) measurement in the diagnosis and dynamic inspection of esophageal cancer. Methods:The serum SA concentration of 117 esophageal cancer patients, 83 benign disease patiens and 103 normal persons were measured by Honda S. modified fluoresence method. Results: The serum SA level in esophagal cancer patient group was markedly higher than that in the other tow groups. The serum SA levels among the esophageal cancer patients in different tissue types and different clinical pathological stages were also obviously difference (P<0.01) .The serum SA levels was positively related with the differentiation removing degree and clinical pathological advance of the cancer. Moreover, the serum SA levels of the patients who accepted operation to remove the cancer 4 weeks before were markedly lower than that before operation, which would be rebounded again to a high level if the cancer had a relapse or transference late. Conclusions:There was marked clinical significance to measure serum SA for esophageal cancer diagnosis, treatment evaluation and monitoring after operation.