癌胚抗原、肿瘤特异性生长因子联合检测对胸腔积液诊断的意义

Combined assays of tumor marker CEA and TSGF for differential diagnosis of pleural effusion

目的探讨肿瘤标志物癌胚抗原（CEA）联合恶性肿瘤特异性生长因子（TSGF）检测在胸腔积液诊断中的意义。方法采集有胸腔积液患者的血清和胸水样本各165例，其中恶性胸腔积液患者55例，良性胸腔积液患者110例，用化学发光法检测其血清和胸水癌胚抗原（CEA）、肿瘤特异性生长因子（TSGF）的含量。结果恶性胸水组血清CEA、TSGF的阳性率分别为58．8％，54．3％，胸水CEA、TSGF的阳性率分别为75．8％，70．7％；良性胸腔积液组CEA、TSGF血清及胸水的阳性率分别为0、18．4％和0、11．4％，差异有统计学意义（P〈0．01）；两组含量的检测也得出相似的结果。联合检测血清CEA、TSGF诊断恶性胸腔积液的敏感度为85．7％，特异度为97．8％。结论肿瘤标志物CEA、TSGF联合检测，对胸腔积液的鉴别诊断有较好的临床价值。

Objective To study the clinical significance of tumor markers combined assay in the differential diagnosis of pleu.ral effusion. Methods 165 serum and hydrothorax samples were collected from 165 in-patients with pleural effusion. Among them,55 patients were suffered from malignant pleural effusion and 110 patients with benign p leural effusion. The concentration of CEA, and TSGF were determined by chemiluminescence assay. Results In ma- lignant pleural effusion group, the positive rates of serum CEA and TSGF were 58. 8% and 54. 3% respectively, the positive rates of hydrothorax CEA and TSGF were 75.8% ,70.7% respectively. Among them ,CEA and TSGF in malignant group were significantly higher than that in benign pleural effusion group（ P 〈0.01 ）. So as did of the concen- tration. The sensitivity of combined assay with serum TSGF in diagnosing malignant pleural effusion was 85.7% ,with the specificity of 97.8%. Conclusion Tumor markers of CEA and TSGF have high clinical values in the differential diagnosis of pleural effusion. The combined assay with TSGF is recommended.