急性心肌梗死患者血清胎盘生长因子的动态变化

Dynamic Changes of Serum Placental Growth Factor in Patients With Acute Myocardial Infarction

目的:观察急性心肌梗死(AMI)患者血清胎盘生长因子(PlGF)及超敏C-反应蛋白的动态变化及意义。方法:测定60例AMI患者(AMI组)发病第12小时、第3天、第7天血清中PlGF及超敏C-反应蛋白水平,并于第14天行超声心动图检测。另选40例健康体检者为正常对照组。PlGF采用酶联免疫吸附双抗体夹心法原理定量测定。结果:AMI组发病第12小时、第3天PlGF均显著高于正常对照组,差异有统计学意义(P<0.05),第7天与正常对照组相比差异无统计学意义(P>0.05);第12小时、第3天、第7天超敏C-反应蛋白均显著高于正常对照组,差异有统计学意义(P<0.05);血清PlGF与左心室射血分数呈显著负相关(r=-0.654;P<0.01),与左心室舒张末期容积和左心室舒张末期内径均呈显著正相关(r=0.845,0.684;P<0.01)。结论:AMI时患者血清PlGF水平显著增高,AMI后第3天达到相对高值,第7天降至正常人群水平。PlGF水平可能影响左心室重构。

Objective ： To assess the dynamic changes of serum placental growth factor （PIGF） and high-sensitivity C-reactive protein （hsCRP） in patients with acute myocardial infarction（AMI）. Methods ： Sixty AMI patients were studied for serum PIGF by ELISA at 12 hours, 3 days and 7 days of AMI onset ; the cardiac uhrasonography was performed at 14 days of onset. Forty healthy subjects were studied as normal control group. Results：The level of PIGF at 12 hours and the 3 days of AMI onset were significantly raised than in normal control（P 〈 O. 05 ） and it showed similar level with in normal control at 7 days （P 〉 0.05 ）. The level of hsCRP at 12 hours, 3 days and 7 days of onset were significantly higher than in normal control group （P 〈 0.05 ）. Serum PIGF had a negative correlation with left ventricular ejection fraction（r = -0. 654;P 〈 0. 01 ）, had a positive correlation with left ventricular end-diastolic volume and left ventricular end-diastolic diameter （ r = 0. 845, r = 0. 684 respectively ; P 〈 0. 01 ）. Conclusion：The level of PIGF were significantly raised in AMI, it could reach the peak at 3 days of onset, and be back to the normal at 7 days. The level of PIGF might influence the left ventricular remodeling.