摘要
目的:探讨双柏凝胶剂的制备及质量控制。方法:以卡波姆-940、甘油等基质与中药提取液混合制备凝胶,采用TLC鉴别凝胶中大黄、黄柏、侧柏叶,采用HPLC测定其中大黄素的含量。结果:大黄素在0.04～0.40mg·ml^(-1)浓度范围内呈良好的线性关系(r=0.9998),平均回收率为99.11%,RSD=1.04%。结论:双柏凝胶剂制备方法操作简单,工艺可行,含量测定方法准确,质量控制标准合理。
Objective： To prepare Shuangbai gels and to establish a quality control method. Method： Carbopol-940 and glycerin were used as a gel base ; The radix et rhizome rhei, cortex phellodendri chinensis, and cacumen platycladi were identified by TLC. The content of emodin was determined by HPLC. Result： The linear range of emodin was 0.04 -0.40 mg·ml^-1（ r = 0. 999 8 ）. The average recovery was 99.11%, and the RSD = 1.04%. Conclusion ： The prepraration of Shuangbai gels is reliable, the method is accurate, and the standard of the quality control is reasonable.
出处
《中国药师》
CAS
2008年第12期1413-1415,共3页
China Pharmacist
基金
广西卫生厅计划课题(Z2003069)
