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获得性再生障碍性贫血的发病机制及治疗 被引量：3

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摘要 近十年来，关于获得性再生障碍性贫血（AA）发病机制及治疗的研究有了很大进展，普遍公认的治疗方法有．免疫抑制剂联合治疗（IST）和同种异基因造血干细胞移植（Allo-SCT），使本病的预后有了明显的改善。儿童极严重再障的5年生存率已从20世纪80年代的37％上升到90年代的83％，年龄％20岁重型再障患者10年生存率达73％，21～30岁者达75％，31～40岁者达66％，〉40岁者达47％。以下将分述近年来在这方面的进展及临床应用。
作者 王耀平
机构地区 上海交通大学医学院附属上海儿童医学中心
出处 《国际输血及血液学杂志》 CAS 2009年第1期15-18,共4页 International Journal of Blood Transfusion and Hematology
关键词 获得性再生障碍性贫血 联合治疗 发病机制 同种异基因造血干细胞移植 10年生存率 重型再障 免疫抑制剂 5年生存率
分类号 R72 [医药卫生—儿科] R5 [医药卫生—内科学]
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参考文献12

  • 1Kurre P, Johnson FL, Deeg HJ, Diagnosis and treatment of children with Aplastic Anemia. Pediatr Blood Cancer, 2005:45 (6) : 770-780.
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同被引文献15

  • 1杨朴.环孢霉素A 康力龙治疗慢性再生障碍性贫血[J].医药论坛杂志,2004,25(16):15-16. 被引量：3
  • 2Audino AN,Blatt J,Carcamo B,et al.High-dose cyclophosphamide treatment for refractory severe aplastic anemia in children[J].Pediatr Blood Cancer,2010,54(2):269-272.
  • 3Bing H,Siyi Y,Wei Z,et al.The use of anti-human T lymphocyte porcine immunoglobulin and cyclosporine a to treat patients with acquired severe aplastic anemia[J].Acta Haematol,2010,124(4):245-250.
  • 4Jiang S,Wang Y,Shi W,et al.The benefit of ATG in immunosuppressive therapy of children with moderate aplastic anemia[J].Pediatr Hematol Oncol,2009,26(5):313-320.
  • 5Chang MH,Kim KH,Kim HS,et al.Predictors of response to immunosuppressive therapy with antithymocyte globulin and cyclosporine and prognostic factors for survival in patients with severe aplastic anemia[J].Eur J Haematol,2010,84(2):154-159.
  • 6Kamio T,Ito E,Ohara A,et al.Relapse of aplastic anemia in children after immunosuppressive therapy:a report from the Japan Childhood Aplastic Anemia Study Group[J].Haematologica,2011,96(6):814-819.
  • 7Tichelli A,Schrezenmeier H,Socié G,et al.A randomized controlled study in patients with newly diagnosed severe aplastic anemia receiving antithymocyte globulin (ATG),cyclosporine,with or without G-CSF:a study of the SAA Working Party of the European Group for Blood and Marrow Transplantation[J].Blood,2011,117(17):4434-41.
  • 8邓家栋 杨崇礼 杨天楹 等.临床血液学[M].上海：上海科学技术出版社,2001.1085-1090.
  • 9桑玉旗.环孢素A治疗再生障碍性贫血的疗效因素分析[J].临床血液学杂志,2008,21(3):268-269. 被引量：2
  • 10张乃红.环孢霉素A治疗再生障碍性贫血的疗效和机制[J].中华血液学杂志,1998,19(4):218-220. 被引量：79

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国际输血及血液学杂志
2009年 第1期

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