虎杖提取物对急性痛风性关节炎大鼠血清PGE2水平的影响

Probable Mechanism of Polygonum Cuspidatum Extract on the Gout Arthritis in Rats Subjected to Uric Acid Crystallization of Sodium

目的:研究虎杖提取物防治急性痛风性关节炎的作用机理。方法:采用尿酸钠结晶(MSU)所致急性痛风性关节炎大鼠模型,放射免疫法(RIA)测定大鼠血清前列腺素(PGE2)的含量,观察虎杖提取物对急性痛风性关节炎大鼠血清PGE2水平的影响。结果:与对照组相比,模型组大鼠PGE2的含量明显升高,虎杖提取物180mg/kg、360mg/kg和痛风定480mg/kg均可显著减少PGE2的含量(P<0.05)。结论:虎杖提取物可能通过降低PGE2的水平来发挥防治急性痛风性关节炎的作用。

Objective： To study the mechanism of Polygonum cuspidatum extract on the gout arthritis in uric acid crystallization of sodium （MSU）rats. Method： After model 12hours, RIA determination the content of PGE2 in serum to study the effect of Polygonum cuspidatum extract on acute gouty arthritis. Results ： Compared with the control group, the content of PGE2 in model group was significantly higher, Polygonum cuspidatum extract of 180 mg/kg, 360mg/kg and tong feng ding 480 mg/kg can significantly reduce PGE2 content （ P 〈 0.05 ）. Conclusion ： Polygonum cuspidatum extract prevention and treatment of acute gouty arthritis possible by reducing the level of PGE2