细胞色素P450与肿瘤

Cytochrome P450 and tumor

当今社会,恶性肿瘤患者日益增多,而且恶性肿瘤的化疗药物的治疗窗很窄,相同剂量的药物在化疗疗效和毒性反应方面存在很大的个体差异。因此,研究肿瘤的发生及个体化治疗成为当前的热点问题。细胞色素P450酶系是自然界中含量最丰富、分布最广泛、底物谱最广的Ⅰ相代谢酶系。本文就细胞色素P450酶系对肿瘤的发生、治疗关系作一综述。

Along with the increase of the population having malignant tumors with time, the effective treatment strategy is far behind the clinical needs. There are significant individual variation in terms of treatment response and toxic profile with the same chemotherapy regimen. Therefore, the research about the occurrence and the individualized treatment of malignant tumor is one of the current hot topics, cytochrome P450（CYPs） is part of I metabolism enzymatic system, and also is the most rich in content, the most widespread in distribution and has the broadest substrate spectrum in nature. This article reviews the relationship between cytochrome P450 and the occurrence and treatment of malignant tumors.