蛋白质精氨酸甲基转移酶的研究进展

Progression of protein arginine methyltransferase

蛋白质精氨酸甲基转移酶(protein arginine methyltransferases,PRMTs)是一种在哺乳动物中常见的酶类,负责对蛋白质底物中的精氨酸进行甲基化。精氨酸甲基化是一种广泛的翻译后修饰方式,涉及RNA加工、转录调控、信号转导、DNA修复等多种细胞过程,并参与调节蛋白质与蛋白质之间的相互作用。PRMTs表达异常与肿瘤、病毒感染、心血管系统疾病等密切相关。

Protein arginine methyhransferases （PRMTs） family is familiar in mammalian. The nitrogens of arginine within polypeptides can be posttranslationally modified to contein methyl groups by PRMTs, a process termed arginine methylation. Arginine methylation is a prevalent post-translational modification implicated in a number of different cellular processes, including RNA metabolism, transcriptional regulation, signal transduction and DNA damage repair, it also participate in regulating protein-protein interactions. The deregulated levels of PRMTs may result in cancer, viral pathogenesis, cardiovascular diseases, and so on.