期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

FGF-1分泌途径的研究进展 被引量：3

Progression of the secretory pathway of FGF-1
下载PDF
导出
摘要 酸性成纤维生长因子-1(FGF-1)由于氨基端缺乏信号肽序列,不能通过经典的内质网-高尔基体途径释放。但在一些应激条件下,FGF-1与S100A13,P40syt1,SK1结合成多蛋白释放复合体,实现跨磷脂膜的出胞转运。FGF-1与许多病理过程有关,因而一些干预FGF-1释放途径的措施为治疗FGF-1介导的疾病提供了新的思路。 Fibroblast growth factor（ FGF-1 ）lacks amino-terminal signal peptide, so it can＇t release through the classical endoplasmic reticulum （ER）-Golgi pathway. Under some stresses, FGF-1 binds S00A13 ,P40Sytl, and SK1 to be a muhiprotein release complex that is released into extracellular compartment across membrane. FGF-1 is involved in many pathological processes, so the measures to disturb or inhibit FGF-1 release pathway provide a new strategy for the diseases directed by FGF-1.
作者 洪灿 曹仁贤
机构地区 南华大学附属第一医院临床医学研究所
出处 《国际病理科学与临床杂志》 CAS 2008年第6期540-543,共4页 Journal of International Pathology and Clinical Medicine
基金 湖南省自然科学基金(06JJ50046)~~
关键词 酸性成纤维生长因子-1 非经典释放 多蛋白释放复合体 fibroblast growth factor-1 non-classical release muhiprotein release complex
分类号 R341 [医药卫生—基础医学]
  • 相关文献

参考文献23

  • 1Prudovsky l, Tarantini F, Landriscina M, et al. Secretion without Golgi[J]. J Cell Biochem, 2008, 103(5) : 1327-1343.
  • 2Prudovsky I, Bagala C, Tarantini F, et al. The intraceliular translocation of the components of the fibreblast growth factor t release complex precedes their assembly prior to export [ J ]. Cell Biol, 2002,158(2) :201-208.
  • 3Chi YH, Kumar TK, Chiu IM, et al. Identification of rare partially unfoled states in equilibrium with the nativeconformation in an all beta-barrel protein [ J ]. J Biol Chem, 2002, 277 ( 38 ) : 34941- 34948.
  • 4Prudovsky I, Mandinova A, Soldi R, et al. The non-classical export routes: FGF-1 and IL-lalpha point theway [ J ]. Cell Sci, 2003, 116 (Pt24) : 4871-4881.
  • 5Grose R, Dickson C. Fibroblast growth factor signaling in tumorigenesis[ J]. Cytokine Growth Factor Rev,2005,16(2) : 179-186.
  • 6Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth- factorsandtheirreceptorsinprostatecancer [ J ]. Endocrine-Related Cancer,2004,11 (4) : 709 -724.
  • 7Takeuchi Y, Daa T, Kashima K, et al. Mutation of 1953 in thyroid carcinoma with an insular component [ J ]. Thyroid, 1999,9 (4) : 377-381.
  • 8MatsunagaH, Ueda H. Evidence for serum-deprivation-induced corelease of FGF-1 and SI00A13 from astrocytes [ J]. Neurochem Int, 2006,49 ( 3 ) : 294-303.
  • 9Soldi R, Mandinova A, Venkataraman K, et al. Sphingosine kinase 1 is acritical component of the copper-dependent FGF-I export pathway[J]. Exp Cell Res,2007,313(15) :3308-3318.
  • 10Landriscina M, Prudovsky I, Manta Carreira C, et al. Amlexanox re-versibly inhibits cellmigration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro[J]. J Biol Chem,2000, 275 (42) : 32753-32762.

同被引文献57

  • 1梁虹,王安利,王维娜.无脊椎动物模式识别蛋白研究进展[J].生理科学进展,2006,37(2):156-159. 被引量：8
  • 2廖俐雅.S100蛋白的研究进展[J].药品评价,2007,4(3):182-184. 被引量：5
  • 3Donato R. RAGE : A single receptor for several ligands and different cellular responses :The case of certain S100 proteins [ J ]. Cur Mol Med, 2007,7(8) :711-724.
  • 4Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles [J]. Biochem Cell Biol, 2001, 33(7) : 637-668.
  • 5Marenholz I, Heizmann CW, Friz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature) [ J]. Biochem Biophys Res Commun, 2004, 322(4) : 1111-1122.
  • 6Moroz OV, Antson AA, Murshudov GN, et al. The three dimensionalstructure of human S100A12 [ J]. Acta Crystallogr D Biol Crystallogr,2001,57 ( Pt1 ) :20-29.
  • 7Heizmann CW, Fritz G, Schafer BW. S100 proteins: structure, functions and pathology [ J ]. Front Biosci, 2002, 7 ( 6 ) : d1356- 1368.
  • 8Hsieh HL, Schafer BW,Cox JA,et al. S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells[ J]. J Cell Sci ,2002,115 ( 15 ) :3149-3158.
  • 9Marenholz I, Heizmann CW, Friz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature) [ J ]. Biochem Biophys Res Commun, 2004, 322(4) : 1111-1122.
  • 10Ostendorp T, Leclerc E, Galichet A, et al. Structural and functional insights into RAGE activation by multimeric S100B [ J ]. EMBO J,2007,26(16) :3868-3878.

引证文献3

二级引证文献25

国际病理科学与临床杂志
2008年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部