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Notch信号通路在脑胶质瘤中的研究进展 被引量：1

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摘要 Notch信号通路通过细胞间受体及配体作用介导信号转导,在系统发育及肿瘤发生、发展等生理病理过程中发挥重要作用。Notch信号通路在脑胶质瘤方面也被广泛研究,Notch配体、受体及其下游基因在脑胶质瘤中都有不同程度的增高,且与胶质瘤级别呈一定的相关性。选择性抑制Notch信号通路,胶质瘤细胞生长受抑、凋亡增加,肿瘤动物模型存活时间延长。最近研究还发现Notch的配体之一DLL4(Deltalike-4)可以抑制肿瘤血管内皮细胞增殖,调控肿瘤血管形成,成为潜在的胶质瘤治疗靶点。
作者 钱春发 尤永平
机构地区 南京医科大学第一附属医院神经外科
出处 《国际神经病学神经外科学杂志》 2008年第6期564-567,共4页 Journal of International Neurology and Neurosurgery
基金 国家自然科学基金资助项目(30672165) 江苏省兴卫工程重点人才项目(RC2007061)
关键词 NOTCH 胶质瘤 DLL4 基因治疗 血管生成
分类号 R739.4 [医药卫生—肿瘤]
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参考文献26

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二级参考文献17

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国际神经病学神经外科学杂志
2008年 第6期

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