摘要
蛋白质糖基化是一种常见的翻译后修饰,几乎50%的蛋白质都被认为具有糖基化修饰.糖基化作用产生大量聚糖,其结构变化与许多生理和病理过程相关,恶性肿瘤的发生侵袭就是其中之一.本文对糖蛋白聚糖的结构和功能进行描述,并且举例说明与肝癌相关的某些糖蛋白聚糖结构的变化.
Glycosylation is a common post-translational protein modification, and almost half of all proteins have been estimated to be glycosylated. Protein glycosylation produces lots of glycans and altered glycan structures are associated with physiological and pathological process, including malignant transformation and invasion. This review describes the structure and function of glycans and highlights changes in glycan structure associated with liver cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第36期4071-4074,共4页
World Chinese Journal of Digestology
关键词
糖基化
聚糖结构
癌症
肝癌
Glycosylation
Glycan structure
Cancer
Liver cancer
