胆囊癌肉瘤的临床病理学特征分析

Clinicopathologic features of gallbladder carcinosarcoma

目的:探讨胆囊癌肉瘤患者的诊断与鉴别诊断,以及治疗方法和预后.方法:我院收治1例胆囊癌肉瘤患者,研究其临床表现及诊疗经过,并进行随访,同时对标本进行病理学检查,再结合有关文献,探讨该病的特点.结果:肿瘤侵犯肝脏并侵犯结肠至肌层.病理可见上皮源性肿瘤成分与间叶源性肿瘤成分同时存在且没有移行现象,且该病预后极差.结论:胆囊癌肉瘤是一种罕见的高度恶性肿瘤,需要与肉瘤样癌等并相鉴别,预后与肿瘤分期有关.

AIM： To study the clinical and pathological feature of gallbladder carcinosarcoma and to investigate its differential diagnosis, treatment and prognosis. METHODS： One case of gallbladder carcinosarcoma was treated in our hospital. We studied this disease with its clinical data, histopathology and immunohistoeheznistry, and relative literature were reviewed, in order to reveal the characteristics of this disease. RESULTS： The tumor had infiltrated into liver and muscular layer of colon. Histopathology and immunohistochemistry showed neoplasm of carcinoma and sarcoma simultaneously coexisted, and no transitional areas were detected between carcinoma and sarcoma. The prognosis of this disease was poor. CONCLUSION： Gallbladder carcinosarcoma is a rare tumor with high malignant neoplasm,which needs to be discriminated from several similar diseases. Its prognosis is correlated with the stage of the tumor.