酪氨酸激酶受体RON在胰腺癌中的表达及意义

Expression of recepteur d'origine nantais in pancreatic cancer and its significance

目的:研究酪氨酸激酶RON(recepteur d'origine nantais)在胰腺癌组织中的表达及其意义.方法:收集胰腺癌组织及相关癌旁组织31例,正常胰腺组织8例,采用免疫组织化学技术检测组织中RON的表达.结果:RON在正常胰腺组织、癌旁组织、胰腺癌组织中均见阳性表达,胰腺癌及癌旁中的表达强度高于正常胰腺组织,胰腺癌RON的表达强度强于癌旁组织(P<0.05).RON表达与患者年龄、肿瘤大小、组织学类型和肿瘤部位等均无关,与胰腺癌临床分期、分化程度及淋巴结转移相关(P<0.05).结论:RON表达量的增多与胰腺癌的发生、发展有关.

AIM： To examine the expression and significance of Tyrosine Kinase Receptor RON in pancreatic cancer and its significance. METHODS： The expression of RON was detected in 31 pancreatic cancer tissue specimens and 31 adjacent pancreatic tissue specimens and 8 normal pancreatic tissues were using immunohistochemistry. RESULTS： The expression of RON was detected in all the pancreatic cancer tissues, the normal pancreatic tissues and in adjacent tissues. The RON expression level in all the pancreatic cancer tissues and adjacent tissues was significantly higher than those of the normal pancreatic tissues; RON expression was higher in pancreatic cancer tissues than in adjacent tissues （P 〈 0.05）. The expression level of RON in pancreatic cancer tissue was correlated with tumor differentiation and clinical stage and lymph node metastasis, and not correlated with age, tumor size, histological type or tumor location （P 〈 0.05）. CONCLUSION： Elevated RON expression may contribute to pancreatic carcinogenesis.