摘要
对分枝杆菌多糖（ＭＰＳ）进行了长期毒性实验。结果：ＭＰＳ１．５、７．５、１５．０μｇ／ｋｇ体重３个剂量组与对照组大鼠在生长发育、食物利用系数、血液常规、生化指标、脏体比和脏器病理检查等方面均无统计学上的显著差异（Ｐ＞０．０５）。表明ＭＰＳ在实验剂量范围内对大鼠无不良影响，提示它在临床上长期使用是安全的。
long- term toxicity test of Mycobacterial polysaccharides(MPS) was carried out. Experimental groups with three different doses (1.5、7.5 and 15.0 μg/kg) of MPS were compared with the control in the parameters of growth ratio, coefficieny of food utilization, routine and specific tests of blood, OW/BW ratio and pathological examinations. Results showed no significant statistical differences between the experimental animals and controls. This study shows that MPS with such test doses has no adverse effect to the rats denoting that MPS can be used for longterm treatment.
出处
《首都医科大学学报》
CAS
1998年第1期13-18,共6页
Journal of Capital Medical University
关键词
分枝杆菌多糖
免疫调节剂
毒性
实验研究
Mycobacterial polysaccharide
immunomodulator
long term toxicity test
