红曲菌代谢产物 lovastatin 的定性定量检测及其作用观察

Determination and Effects of the Cholesterol Biosynthetic Inhibitor Produced by Monascus

用红曲菌对实验性动脉粥样硬化家兔进行治疗，观察红曲菌对高脂血症和动脉粥样硬化病变的影响。结果证实红曲菌能明显降低高胆固醇血症家兔的血胆固醇浓度，并能缓解其动脉粥样硬化病变的进展。通过薄层层析和高效液相的方法对红曲菌的代谢产物进行了定性、定量检测，证实红曲菌在代谢过程中可以产生具有抑制胆固醇合成的物质———ｌｏｖａｓｔａｔｉｎ。

therosclerotic rabbits were treated by administrating Monascus. Changes of atherosclerosis and hyperlipidemia were observed. The experiments confirmed that Monascus may reduce serum cholesterol concentration in hypercholesterolemic rabbits and cease from progress of atherosclerosis. The metabolite of Monascus was determined by using the thin layer chromatographic qualitative analysis method and the HPLC quantitative analysis method. The results showed that lovastatin, an inhibitor of biosythesis of cholesterol, was produced by Monascus.