儿童期单纯肥胖症内分泌系统的变化及临床意义

Endocrine Abnormality in Simple Obese Children

应用放射免疫分析方法及化学发光法，检测７５例单纯肥胖症儿童及５９例同龄健康儿童的空腹血清胰岛素（ＩＮＳ）、三碘甲状腺素（Ｔ３）、生长激素（ＧＨ）、催乳素（ＰＲＬ）及血浆皮质醇（ＣＯＲ）、雌二醇（Ｅ２）水平。发现肥胖儿童较健康儿童胰岛素及雌二醇水平明显增高（Ｐ＜０．００１），生长激素及催乳素水平明显下降（Ｐ＜０．０１），三碘甲状腺素及皮质醇水平无明显变化。肥胖儿童胰岛素水平与体重指数、年龄、身高、体重均呈明显正相关（ｒ＝０．６１、０．４０、０．５０及０．６２，Ｐ＜０．００１及０．０１）。６项激素水平与体重指数的多元逐步回归分析证实胰岛素是影响体重指数的独立因素。

he relationship between endocrine hormone and obesity was studied in 75 simple obese children of ages 6～15 and 59 age matched healthy children. A significant increase in insulin and E2 and decrease in human growth hormone and prolactin in the obese than the normal controls were observed (P all<0.01). There were no differences between two groups in triiodothyronine and COR. Serum insulin level was correlated positively to body mass index (r=0.61,P<0.001), age (r=0.40,P<0.01),height (r=0.50,P<0.001) and weight (r=0.62,P<0.001). Stepwise multivariate regression analysis disclosed that body mass index alone and jointly correlated with insulin level.