阻抗微分法测量小鼠心排血量的实验研究

Study of Measuring Cardiac Output of Mouse in Impedance Differentiation

目的：探讨一种测量２０ｇ以内小鼠心排血量的可行方法，以应用于其他研究。方法：应用ＲＭ－６３００型八道生理仪及针式电极行阻抗微分法测量，根据相应公式计算每搏心输出量。结果：测得正常小鼠的每分钟心输出量为１．６７±０．０９ｍｌ／分，病毒性心肌炎小鼠模型每分钟心输出量为１．１６±０．０５ｍｌ／分。结论：阻抗微分法是测量２０ｇ以内小鼠心排血量的一种可行方法。

Objectives To probe into a feasible method that could survey cardiac output of mouse less than 20g. Methods Impedance differentiation with eightchannel physiogragh,according to the relevant formula to calculate the stroke output. Results The cardiac output of normal mouse is 167±009ml/min,that of viral myocarditis mouse is 116±005ml/min.Conclusions The impedance differentiation is a feasible method to survey cardiac output of mouse less than 20g.