表皮生长因子受体在原发性胆囊癌中的表达及其预后意义

The Expression of Epidermal Growth Factor Receptors(EGFR) in Primary Gallbladder Carcinoa(PGC) and its Relation with Prognosis

目的：探讨表皮生长因子受体（ＥＧＦＲ）在原发性胆囊癌中的表达及其预后意义。方法：３８例原发性胆囊癌石蜡包埋标本，免疫组织化学ＳＰ法。结果：ＥＧＦＲ在原发性胆囊癌中表达的阳性率为（５７．６±３６．７）％，表达呈异质性，ＥＧＦＲ计数与术后生存期呈显著负相关（Ｐ＜０．０５）。ＥＧＦＲ高值组生存期与低值组比较有显著差异（Ｐ＜０．０５），ＥＧＦＲ计数与肿瘤的分化程度、浸润深度呈显著相关关系（Ｐ＜０．０５）），与病理类型及淋巴结转移，无显著相关性。结论：ＥＧＦＲ表达对判断原发性胆囊癌的预后有一定的参考价值。

Objective:The purpose of this paper was to investigete the expression of EGFR in PGC tissue and its signiticance for prognosis Methods:Thirty eight pareffin embedded specimens from primary gallbladder carcinoma tissue were collected. They were examined immunohistochemically.Results:The positive rate of EGFR product in gallbladder cancer tissue was (57.6±36.7)%. The EGFR labelling Index (LI) showed a significant negative correlation with survival of patients after curative resection (P<0.05). The survival periods ware significantly different in patients with low and high EGFR LI. The expression of EGFR correlated significantly with differentiation and invasion (P<0 05), but did not correlate with their pathohistological types and lymph node metastasis.Conclusion:The detection of EGFR in PGC tissue may be useful in judging the prognosis for PGC.