摘要
目的:探讨IFN-和TNF-α在乙型病毒性肝炎发病机制中的作用。方法:采用双抗体夹心ELISA法对96例乙型肝炎患者和30例健康献血员血清中IFN-和TNF-α进行检测,用t检验进行统计学分析和相关性分析。结果:各型乙型肝炎患者血清IFN-和TNF-α水平明显高于对照组(P<0.05);重型肝炎组(xIFN=234.7±16.5;xTNF=359.0±17.2pg/ml)与急性肝炎组(xIFN=174.9±12.0;xTNF=220.6±8.9pg/ml)比较,前者均明显高于后者,差异显著(P<0.05);各型乙型肝炎患者IFN-和TNF-α呈正相关(r=0.24,P<0.05)。结论:IFN-和TNF-α异常增高可能与肝损伤发生有关。
Objective: Studing the effects of IFN and TNFα in pathogenesis of viral hepatitis B. Methods: IFN and TNFα in sera from 96 patients with viral hepatits B and 30 healthy persons were detected by ELISA. The statistical analysises were made by t test. Results: IFN and TNFα in sera from HBV infectors were significantly higher than those in healthy persons (P<005); IFN and TNFα values in patients with fulminant hepatitis were obviously higher than those patients with acute hepatitis (P<0.050; IFN closely related to TNFα (r=0.24,P<0.05). Conclusion: Enhanced IFN and TNFα in sera of patients with HBV infection was involved in liver damage.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1998年第1期57-58,62,共3页
Journal of China Medical University
基金
国家自然科学基金