TAL-1基因与急性T淋巴细胞白血病临床特征的研究

The Relationship between TAL-1 Gene and Acute Lymphoblastic Leukemia

TAL-1基因易位是急性T淋巴细胞白血病中最常见的基因缺陷。为确定TAL-1基因易位与白血病的关系,观察了患者外周血和骨髓TAL-1基因的变化。结果:172例儿童患者中48例有TAL-l基因易位。在发生TAL-1基因缺陷的患者中,除白细胞计数及血红蛋白明显增高外,CD2阳性率明显增高(97.9％),CDl0阳性率则明显减少(12.5％)。观察5年存活率,TAL-1易位患者存活时间相对较长,但对患者预后的影响尚须进一步研究。

Alteration of the TAL-1 locus is the most common genetic defect in childhood T-cell acute lymphoblastic leukemia. To determine the probable relationship between rearrangements of TAL-1 and leukemic phenotype, we studied leukemic peripheral blood or bone marrow samples from 172 children. Forty-eight of the samples had local rearrangements of the TAL-1 locus. In addition to a higher white blood cell count and hemoglobin in these patients, the positive rate of CD2 was markedly increased (97. 9 %) and the positive rate of CD10 was markedly reduced (12. 5 %). There was a trend toward improved five years', sur-vival in patients with TAL-1 rearrangement. The prognostic significance of TAL-1 gene rearrangements in T-cell acute lymphoblastic leukemia deserves further study.