摘要
目的:探讨更年期激素替代治疗对脂蛋白和载脂蛋白的影响。方法:将45例更年期病人按2∶1随机分为2组,实验组30例接受口服国产短效戊酸雌二醇每天1mg,对照组15例口服结合雌激素每天0.625mg,并与醋酸甲孕酮4mg连续序贯应用治疗16周,分别于用药前、用药后9周、16周测定血脂蛋白和载脂蛋白水平。结果:实验组HDL、ApoAⅠ上升,ApoB、ApoCⅢ、ApoE下降;对照组HDL、ApoAⅠ、ApoAⅡ上升,ApoE下降。用药后9周,对照组ApoAⅠ和ApoCⅡ明显高于实验组;用药后16周,对照组ApoAⅡ和ApoCⅢ明显高于实验组;其余血脂和载脂蛋白结果,两组间差异无显著性。结论:激素替代治疗对血脂构成有正性作用。
Objective: To determine the effects of postmenopausal hormone replacement therapy on serum lipoprotein and apolipoprotein. Methods: 45 patients were divided at random into 2 groups: 30 were each given 1 mg of domestic estradiol valerate, 15 were each given 0.625 mg of estradiol conjugated estrogen daily. 4 mg of medroxyprogesterone acetate was added sequentially in both groups. Serum lipoprotein and apolipoprotein were measured before and after treatment (week 9 and week 16). Serum estradiol and FSH were measured at the same time. Results: HDL, ApoAⅠ increased and ApoB, ApoCⅢ, ApoE decreased in the experimental group; HDL, ApoAⅠ, ApoAⅡ increased and ApoE decreased in the control group. After 9 weeks' treatment, ApoAⅠ and ApoCⅡ of the control group were higher than those of the experimental one; after 16 weeks' treatment, ApoAⅡ and ApoCⅢ were higher than those of the experimental one. Conclusion: Postmenopausal hormone replacement therapy may improve the constitution of serum lipoprotein and apolipoprotein.
出处
《北京医科大学学报》
CSCD
1998年第1期70-72,共3页
Journal of Peking University(Health Sciences)
关键词
更年期综合征
激素替代疗法
脂蛋白
载脂蛋白
Estrogens/ther use Climacteric Apolipoproteins A/blood Apolipoproteins B/bloodApolipoproteins E/blood Lipoproteins, HDL/blood