全光谱紫外线照射对动脉血栓的效应

Thrombolytic effect of fullspectrum ultravioletirradiation on canine femoral arterial thrombus models

目的：探讨紫外线（ＵＶ）对血栓的效应方法：２６只健康成年犬被随机分为４组，复制股动脉血栓模型后，ＵＶ＋尿激酶（ＵＫ）组和ＵＫ组（各８只）即静脉０１４×１０４Ｕ／ｍｉｎ点滴ＵＫ，同时ＵＶ＋ＵＫ组还行胸腹部ＵＶ８００ｃｍ２，４４７７２ｍＪ／ｃｍ２照射１次；ＵＶ组（５只）只同法照射ＵＶ，不用ＵＫ；对照组（５只）既不用ＵＫ也不照ＵＶ，观察各组血栓溶解情况．结果：血栓溶通率对照组为０／５，ＵＶ组０／５，ＵＫ组４／８，ＵＶ＋ＵＫ组７／８；残余血栓湿重ＵＶ组明显轻于对照组，ＵＶ＋ＵＫ组明显轻于ＵＫ组（Ｐ＜００１）；血栓溶通时间ＵＶ＋ＵＫ组较ＵＫ组缩短（Ｐ＜００１）；溶通血栓所用ＵＫ剂量ＵＶ＋ＵＫ组低于ＵＫ组（Ｐ＜００１）结论：强红斑量ＵＶ大面积照射具有促溶栓效应；

Aim:To elucidate thrombolytic effect of ultraviolet(UV) irradiation on skins. Methods:Twentysix healthy adult dogs were randomly divided into 4 groups Immediately after femoral arterial thrombus models being formed,UV+urokinase(UK) and UK groups( each n= 8) were intravenously 1400U/min administered with UK, while UV+ UK group receiving 800 cm2,44772 mJ/cm2 UV irradiation on thoracoabdominal skins once as well;UV group(n=5) were irradiated in the same way as UV+UK group,without UK administration;and control group got neither UKnor UVtreatmentThen thrombolytic status in each group was observed finally. Results:Twentyfour hours postexperiment, successfully thrombolytic rates of control,UV,UK and UV+UK groups were 0/5, 0/5, 4/8 and 7/8,respectively,with UV group having significantly lower wet weights of residual thrombuses than control group,and UV+UK group lower than UK group(P<001);besides,thrombolytic time of UV+UK group was shorter than that of UK group(P<001),with UV+UK group using less UK dosage needed to successful thrombolysis than UK group(P<001). Conclusion: These data suggest that UV irradiation,with stronger erythema reaction and larger irradiation area,upon canine thoracoabdominal skins once has slight thrombolytic effect,and that combined application of UV irradiation and urokinase administration appears significant cothrombolytic function