肾癌组织中NM23与P53蛋白的合成及其临床意义

Synthesis of NM23 and P53 protein in renal cell carcinoma and its clinical significance

目的：探讨ｎｍ２３和ｐ５３基因与肾癌发生、发展的关系．方法：应用免疫组化ＳＡＢＣ法，检测５５例肾癌及４２例癌旁组织的ＮＭ２３和Ｐ５３蛋白．结果：肾癌组织中ＮＭ２３和Ｐ５３蛋白阳性率分别为６７２％和３０２％，二者在阳性强度上存在负相关（ｒ′ｓ＝－０４６１，Ｐ＜００５）．两种蛋白产物的合成与肿瘤组织学分级和预后有关，而与包括肿瘤大小、临床分期和细胞类型在内的诸因素无关．结论：ｎｍ２３和ｐ５３基因可能共同参与了肾癌的发生。

Aim:To study the relationship between nm23 and p53 gene expression and the carcinogenesis and the development of human renal cell carcinoma (RCC) Methods:Synthesis of NM23 and P53 protein in the cancerous tissues of 55 patients with RCC and 42 pericancerous tissues were studied with immunohistochemical methodResults:The positive rates of NM23 and P53 protein in RCC were 672% and 302% respectively There was significant negative correlation between NM23 and P53 protein positive degree(r′s=-0461,P<005)Synthesis of NM23 and P53 protein wasn′t associated with size, clinical stage and pathological classification of the tumor, but was correlated with histological differention degree of the RCC and prognostic evaluation of the patients Conclusions:The results show that nm23 and p53 gene may play some roles in occuring and development of the RCC They may be useful in judging malignance of the RCC and evaluating prognosis of the patients