阿霉素脂质体经肝动脉给药治疗大鼠肝肿瘤

Treatment of hepatomabearing rats with liposomeencapsulated adriamycin administered into the hepatic artery

目的：观察阿霉素脂质体（ＬＡＤＭ）经肝动脉给药对大鼠肝肿瘤的疗效，并与阿霉素水溶液（ＡＤＭ）及阿霉素加空白脂质体（ＡＤＭ＋ＢＬ）相比较．方法：应用改良逆相蒸发法制备ＬＡＤＭ，建立大鼠移植性Ｗ２５６肝癌模型并随机分为４组，经肝动脉分别灌注生理盐水，ＡＤＭ（２ｍｇ／ｋｇ），ＡＤＭ＋ＢＬ（２ｍｇ／ｋｇ）及ＬＡＤＭ（２ｍｇ／ｋｇ）．结果：与ＡＤＭ及ＡＤＭ＋ＢＬ组相比，经ＬＡＤＭ治疗的大鼠生存期显著延长（Ｐ＜００１），对肿瘤生长的抑制更为明显（Ｐ＜００１），肿瘤坏死更广泛、更彻底．结论：ＬＡＤＭ经肝动脉给药治疗肝癌疗效肯定，且优于ＡＤＭ与ＡＤＭ＋ＢＬ．

Aim:To observe the therapeutic effects of liposomeencapsulated adriamycin(LADM)administered into the hepatic artery for hepatoma in rats fand compare it with that of adriamycin solution(ADM) and ADM plus blank liposome (ADM+BL). Methods:LADM was prepared by the improved reversephase evaporation methodNormal saline,ADM(2 mg/kg),ADM+BL(2 mg/kg),LADM(2 mg/kg) was injected via the hepatic artery in rats bearing liver W256 carcinosarcoma tumor,which had been divided into 4 groups at random, respectively. Results:Compared with animals treated by ADM or ADM+BL, the survival time was prolonged in animals received LADM significantly (P<001),the inhibition of tumor growth was more significant (P<001)and necrosis much more extensive Conclusion: Hepatic arterial infusion of LADM was more effective than ADM and ADM+BL in the treatment of hepatoma 