C反应蛋白与冠状动脉病变的相关性分析

Relationship between C-reactive Protein and Pathological Changes of Coronary Artery

目的分析血清C反应蛋白水平与冠状动脉病变程度及范围的关系。方法根据冠状动脉造影结果将138例患者分为正常对照组(n=32)及冠脉病变组(n=106),分析他们的血清CRP水平。结果CRP水平在正常组、轻度狭窄组、中度狭窄组、重度狭窄组、完全闭塞组逐步增高(P<0.01),在单支病变组、双支病变组及三支病变组中亦呈逐步升高趋势(P<0.01)。结论CRP浓度与冠脉病变程度及范围密切相关,对冠心病的病变程度及预后具有预测价值。

Objective To analyze the relationship between c-reactive protein（CRP） and the area and extent of pathological changes in coronary artery. Methods 138 patients were divided into two groups according to the result of CAG. The normal control group had 32 patients. The coronary artery disease group had 106 patients. The CRP levels of the two groups were analyzed. Results The CRP levels in normal control group,paranormal group, middle stenosed group, heavy stenosed group and occlusive group were increased （P 〈 0.01 ）. The CRP levels of 1-vessel disease group, 2-vessel disease group and 3-vessel disease were increased progressively also（P〈 0.01 ）. Conclusion CRP level has closely relationship with pathological changes of coronary artery. It may be the predictor factor of patients condition in coronary artery disease.