血浆脑钠肽浓度对心力衰竭患者评价预后的临床观察

Clinical Study of the Relationship between Blood B-type Natriuretic Peptide Level and Heart Dysfunction

目的观察血浆脑钠肽浓度和心脏超声,心胸比随心功能改善的数值关系,探讨血浆BNP浓度对心衰病人预后判断的意义。方法比较165例心功能不全患者治疗前、治疗后1个月及3个月的左室射血分数(LVEF)、心胸比值及BNP浓度。结果血浆BNP水平低的患者预后好,反之预后差;并BNP水平在1个月就有变化,在3个月LVEF及心胸比才有变化。结论BNP水平与心力衰竭患者的预后有关;并且这种变化早于心脏功能指标LVEF及心胸比的变化。

Objective To evaluate the value of BNP in prognosis of patients with heart failure by studying the correlation between blood BNP level and severity of heart dysfunction which was assessed by functional classification,and cardiothoracic ratio （CTR）. Methods 165 patients accepted treatment according to guidline for heart failure. Blood BNP,LVEF and CTR were measured before treat,one month after treat and three months after treat,to evaluate the value of BNP level in short-term prognosis in patients of heart failure. Results When the BNP level was more lower, prognosis of the patients would be better. During three-month follow-up peried,BNP levels,LVEF and CTR were observed, blood BNP concentration decreased in one month and much more in three months（P〈 0.05）. Conclusion The change of blood BNP level after treatment can reflect treatment-responsiveness in heart failure patients,increase of BNP level suggested poor prognosis. Patients with BNP level decreased greatly had good prognosis than those with BNP level decreased slightly. BNP can be a predictor for short-term prognosis.