4-哌啶醇的精制工艺研究

Research on Purification Process of 4-Hydroxypiperidine

4-哌啶醇是医药产品的重要中间体,新开发的药物如抗精神病药物氟哌碇醇、癸酸氟哌啶醇等都含有哌啶醇结构。因为4-哌啶醇具有止痛作用,还可用来合成口服止痛专利药和治疗神经性疼痛的专利药物,如止痛药哌吡唑酮、芬太尼(Fentanyl)和神经性疼痛治疗药氟哌啶醇(Haloperidol)等。

In the synthesis of 4-hydroxypiperidine only the product with most of its salt can be obtained owing to its strong protophilic property,so the free title compound can't be separated and purified from its salt with ordinary recrystallization process at all.The present article provides a facile and efficient method to obtain free title compound based on cheap, less pollutant compounds as raw materials with simple purification process to refine 4- hydroxypiperidine from its salt.The process is suitable to its commercial production for its low costs,less pollution and simplicity of process.The recovery rate of the process was 95%.