稀土姜黄素大环配合物的合成、表征及其荧光性质和抑菌活性研究

Synthesis,Characterization and Antibacterial Activity of Rare Earth Macrocylic Complexes of Curcumin

以稀土硝酸盐作为模板,用1,6-己二胺、乙二胺和姜黄素为原料,在乙醇溶液中合成了8种稀土姜黄素大环配合物REL1L2(NO3)3.4H2O(RE=Eu、Dy、Sm、Ce),并由元素分析、1H NMR、摩尔电导、热重-热差分析、红外光谱、紫外-可见吸收光谱等对其进行了结构表征,分析了配合物的热稳定性,研究了配合物在室温下的荧光性质,结果表明配合物表现出相应姜黄素的特征发射。姜黄素和配合物的生物活性测试表明,合成的8种稀土配合物具有抑菌生物活性功能。

Rare earth macrocyclic complexes of curcumin RE L^1L^2 （NO3 ）3 .4H2O（RE = Eu,Dy,Sm,Ce）have been synthesized by the template reaction of rare earth（ Ⅲ ）nitrate, ethylenediamine, 1,6-hexanediamine and curcumin in alcohol solution. The composition and thermal stability of the complexes were characterized by elemental analysis,^H NMR, molar conductivity, IR, UV-Vis and thermal analysis. The fluorescence spectra of complexes at room temperature showed the characteristic emissions of ligand. The tests of antibacterial activity indicated that they had antibacterial property for the testing bacterium.