脑康灵胶囊的急性和长期毒性试验

The acute and chronic toxicity test of Naokangling capsula(NKL)

目的：研究脑康灵胶囊的毒性。方法：采用一日耐受量法和长期毒性法。结果：脑康灵胶囊毒性极低，无法测得LD50，小鼠一日最大耐受量为40g/kg体重（灌胃），相当于人临床用药量的200倍，本药3g/kg、9g/kg分别给大鼠灌胃120天，和对照比较，不影响大鼠生长发育，不影响造血功能、肝功能及肾功能。肉眼观察及病理切片证实给药组大鼠心、肝、脾、肺、肾、脑、胃、肠、肾上腺、甲状腺、睾丸或卵巢在外观形态及组织学上均无明显异常变化。此外，本药尚有使大鼠胸腺增重、促进血红蛋白合成等有益作用。结论：在所试验剂量下未发现脑康灵的毒性反应。

Objective:To study toxicity of NKL capsula.Methods: Maximal tolerance dose(ig) in one day chronic toxicitymethods were used. Results:The acute toxicic of NKL is too low to assay it' s LD50,it's maximal tolerance dose(ig) in oneday is 40g/kg that equals 200 times as people's alinic dose. NKL 3.9g/kg ig for 120 days didn't influence the growth andfunction of hematopoietic system,liver,renal of rat,the histological structure of all organa had no any change, but it couldenhance hemoglobin synthesis and thymus weight of rat. Conclusion: Had no any toxicity of NKL under tested dose.