膀胱癌患者血清中谷胱甘肽S-转移酶的研究

Increased the serum glutathione S-transferase content in patient with bladder cancer

目的：测定膀胱癌患者血清中谷胱甘肽S-转移酶（GST）活性，观察该酶在膀胱癌中的作用。方法：化学比色法对54例膀胱癌患者行GST测定。结果：膀胱癌患者血清SGT平均值较对照组明显升高，膀胱癌患者术后CST降低，与对照组无显著性差异；GST含量在膀胱癌分级分期之间无显著性差异。结论：GST与膀胱癌的发生及发展有关，与膀胱癌恶性度的关系有待于进一步探讨。

Objective:The glutathione S-transferase (GST) content has been studied in patient with bladder cancer to observe the value of GST in blader cancer. Methods: The serum content of GST in bladder cancer patients has been measuredwith chemo-chromatometry. Results: The mean value of serum GST is much higher in bladder cancer patient than in controlgroup.The GST content is reduced oher tumor being resected and there is no significant differences compared to controlgroup.The GST content has no significant differences among the grade and stage. Conclutions:The results demonstrate therelationship between the GST content and development of bladder cancer. But the relationship between the GST content andthe degree of malignanc y needs further investigation.